International Finance and Financial Crisis Case Study

International Finance and Financial Crisis - Case Study Example They should oversee if the sources of funds have an undisrupted flow and if they are able to pay their creditors. Having a clear understanding, the company should try to maximise the cash positions. In 2008, Woolworths had net cash flow of 39.2 millions in comparison to 27.1 millions in 2007. In due contrast to it, the company had 2.2 millions of net cash flow in 2003. So, it can be said Woolworths took required measures to have the increased cash flow during the time of crisis. Identify and aggressively minimise operational risks - The companies, amidst financial crisis, should try to identify and reduce all sorts of avoidable day-to-day risks. During crisis, it is desirable that the companies follow the basics. The operations generated over 61.7 millions in 2008, a drastic increase over the previous year. Conduct rigorous scenario planning - During crisis the companies should also take a proper stock of the economic scenario. They should strategise on the basis of the GDP growth, currency depreciations, etc. Woolworths Group scrapped the idea of paying interim dividend in 2008 considering the net loss it has incurred and the global meltdown. Review business performance and prepare for divestitures - The c... They should strategise on the basis of the GDP growth, currency depreciations, etc. Woolworths Group scrapped the idea of paying interim dividend in 2008 considering the net loss it has incurred and the global meltdown. Review business performance and prepare for divestitures - The company, to sustain and survive the crisis, should continuously review its performance and take necessary steps, as and when required. Also, the company should prepare itself for necessary divestments to increase the cash inflow. As the cash inflow was great for Woolworths, so we can say that the company took regular assessments of its business performance. Maintain the confidence of key stakeholders - Any company that wants to stay floated for long term, knows the value of its stakeholders. Relationship with shareholders, suppliers and customers if once lost can not be regained. The revenue has increased in 2008 compared to 2007 for Woolworths Plc and also there are no bank overdrafts in the year. Dividend Policies, Capital Structure and the Shareholders' Wealth Share-holders are the true owners of any company. And the dividend is the earning of the owner because of his stock holding on the basis of the company's profit. Apart from the capital yield (which a share-holder might earn, if he sale away the share), earning of dividend is the reason of purchasing shares by the shareholder. If a company earns profit from its professional and operational activities, the management can either retain the profit or future investments (called retained profit or retained earning) under the head of 'reserve and surplus' in the balance sheet or the management of the company can distribute the profit among its

Experience of Novice Nurses with NIV in General Wards

Experience of Novice Nurses with NIV in General Wards Experience of novice nurses caring patients with non-invasive ventilation in general wards. Non invasive ventilation (NIV) is used to provide respiratory pressure support to upper airway by using external masks without the insertion of endotracheal tube. It is mostly used for the early management of acute respiratory failure (ARF) (Rose and Gerdtz, 2009) and chronic obstructive pulmonary diseases (COPD) ( Penuelas, Frutos-Vivar Esteban, 2007). NIV is considering less intensive than mechanical ventilation, therefore some clinicians manage these patients outside the intensive care unit (ICU), particularly in hospitals where ICU beds are unavailable (Farha et al., 2006, Hill, 2009). One audit report revealed that inappropriate use of NIV outside the ICU is associated with higher mortality (Sumner and Yadegafar, 2011). Its increasingly usage outside the ICU, lead less experienced nurses to care for these patients’ results in quality care compromised. Previous studies have identified the following factors that contribute towards treatment failure with NIV is lack of know ledge and experience about the regulation of NIV (Kallet, 2009, Lopez et al., 2006, Lopez-Campos et al., 2006, Elliott et al., 2011), inappropriate guideline (Sinuff et al., 2007), patient-ventilator asynchrony, poor judgment about the appropriate mask selection, patient intolerance (Hess, 2011) and delay in patient care at ward level (Elliott et al., 2011). Safe delivery of NIV can be assured when the patient received care from experienced, educated and well trained staff (Rose and Gerdtz, 2009). Previous studies had explored the experiences of experienced nurses worked in ICU and identified that experienced nurses are using their practical knowledge to select the appropriate mask to patient face. They are using their communication skills to gain control on patient breathing and using their clinical experiences to solve the problems and avoiding delays in adjusting the ventilation (Sà ¸rensen et al., 2013) and providing reassurance to immobilized patients and protect them from errors (Acebedo-Urdiales et al., 2014). There is another study that covers the perspectives of general ward nurses about the NIV, is not generalizable study because it was conducted only in one hospital. However, data revealed that 67% nurses didn’t get involved in the decision making process and were inadequately informed. Even they did not received adequ ate consultation from physicians and medical emergency team and mostly, all nurses in medical wards state that training was inadequate about the NIV (Cabrini et al., 2009). Most of the studies have viewed the experiences of competent nurses in ICU or general ward; however no study has explored the experiences of novice nurses caring the patient with NIV in general ward. Therefore, the purpose of my study is to explore the experiences of novice nurses caring the patient with NIV in medical ward. The one of the reason for selecting this topic is my own area of practice and my experience of being a novice nurse in medical ward in Pakistan. I remembered that when I was assigned with NIV patient, I really felt very anxious and worried. Because, I didn’t have any idea about the BIPAP machine like how it is operated, what assessment I need to do in patient condition to monitor the effectiveness of treatment. Sometime, I felt hesitate to consult with physician about the patient’s condition, because of my lack of knowledge, skills and training about the NIV. Therefore, some time I had a fear of harming to patient. My colleagues also had shared the same experiences and feeling with me. For literature search, I have used these electronic databases: CINAHL (15), PubMed (45), Embase (32) and Scopus (35). I have developed the keywords from Medical Subject Headings (MeSH) from each database. I have used these keywords for literature search: work experience; job experience; experience; experiential learning; nursing knowledge; nursing role; nurse-patient relations; job satisfaction, nursing practice; critical care nursing; education, nursing; staff nurses; nurse attitudes; decision making; nurse-physician relations evaluation; new graduates nurse; staff development, nursing care; nurses; novice nurses; respiration, artificial; noninvasive ventilation; noninvasive ventilation; non-invasive ventilation. Reference lists of relevant papers were also checked to identify other potentially relevant literature and take the assistance from nursing librarian. The inclusion criteria for each database were paper published in the English and between the periods of 1 January 2005 to 3 1 March 2015. I have also used the Boolean operators to limit my search results. The reason for such limitation is to get the relevant literature about my area of interest. Total number of paper which I get from each database is 127 documents. Once, I done with literature search, I started to read the abstract of each article and select the relevant and near relevant article to my research purpose and eliminate those which I found irrelevant. Out of 127, 26 articles were selected, review critically and develop themes like factors for NIV failure, lack of knowledge and skills etc .The difficulty which I faced during literature search was I cannot be able to remove the duplicate articles from each databases. As, no study has viewed the experience of novice nurses, therefore I would like to conduct the research build on this research question that â€Å"what are the experiences of novice nurses, while caring the NIV patients in general wards?† This study will explore the experiences of novice nurses and uncover the challenges which novice nurses are facing at intrapersonal, interpersonal or organizational level while caring the patient with NIV. Moreover, this study will highlight the need for staff training. Because, through proper training of staff, it’s eliminates those factors which contributed towards NIV failure in ARF patients and provides quality patient care. In these studies, novice nurse is defined as â€Å"nurses who are new graduates or have limited experience in nursing care particularly with NIV patients† (CINAHL). The reason for selecting the general wards setting is as my area of specialty in medical ward and most of the time, general wards staffs are less experienced and untrained comparatively to ICU staff. References: ACEBEDO-URDIALES, M. S., MEDINA-NOYA, J. L. FERRE-GRAU, C. 2014. Practical knowledge of experienced nurses in critical care: a qualitative study of their narratives. BMC Med Educ, 14, 173. CABRINI, L., MONTI, G., VILLA, M., PISCHEDDA, A., MASINI, L., DEDOLA, E., WHELAN, L., MARAZZI, M. COLOMBO, S. 2009. Non-invasive ventilation outside the Intensive Care Unit for acute respiratory failure: the perspective of the general ward nurses. Minerva Anestesiol, 75, 427-33. ELLIOTT, M., CROOKES, P., WORRALL-CARTER, L. PAGE, K. 2011. Readmission to intensive care: a qualitative analysis of nurses perceptions and experiences. Heart Lung, 40, 299-309. FARHA, S., GHAMRA, Z. W., HOISINGTON, E. R., BUTLER, R. S. STOLLER, J. K. 2006. Use of Noninvasive Positive-Pressure Ventilation on the Regular Hospital Ward: Experience and Correlates of Success. Respiratory Care, 51, 1237-1243. HESS, D. R. 2011. Patient-ventilator interaction during noninvasive ventilation. Respir Care, 56, 153-65; discussion 165-7. HILL, N. S. 2009. Where should noninvasive ventilation be delivered? Respir Care, 54, 62-70. KALLET, R. H. 2009. Noninvasive ventilation in acute care: controversies and emerging concepts. Respir Care, 54, 259-63. LOPEZ-CAMPOS, J. L., GARCIA POLO, C., LEON JIMENEZ, A., ARNEDILLO, A., GONZALEZ-MOYA, E. FENANDEZ BERNI, J. J. 2006. Staff training influence on non-invasive ventilation outcome for acute hypercapnic respiratory failure. Monaldi Arch Chest Dis, 65, 145-51. LOPEZ, A. D., SHIBUYA, K., RAO, C., MATHERS, C. D., HANSELL, A. L., HELD, L. S., SCHMID, V. BUIST, S. 2006. Chronic obstructive pulmonary disease: current burden and future projections. Eur Respir J, 27, 397-412. PENUELAS, O., FRUTOS-VIVAR, F. ESTEBAN, A. 2007. Noninvasive positive-pressure ventilation in acute respiratory failure. Canadian Medical Association Journal,177 , 1211–1218. ROSE, L. GERDTZ, M. F. 2009. Review of non-invasive ventilation in the emergency department: clinical considerations and management priorities. Journal of Clinical Nursing, 18, 3216-3224. SINUFF, T., KAHNAMOUI, K., COOK, D. J. GIACOMINI, M. 2007. Practice guidelines as multipurpose tools: a qualitative study of noninvasive ventilation. Crit Care Med, 35, 776-82. SØRENSEN, D., FREDERIKSEN, K., GRØFTE, T. LOMBORG, K. 2013. Practical wisdom: A qualitative study of the care and management of non-invasive ventilation patients by experienced intensive care nurses. Intensive and Critical Care Nursing, 29, 174-181. SUMNER, K. YADEGAFAR, G. 2011. The utility and futility of non-invasive ventilation in non-designated areas: Can critical care outreach nurses influence practice? Intensive and Critical Care Nursing, 27, 211-217.

Isolation in Faulkners Light in August Essay -- Light August Essays

  Isolation in Light In August  Ã‚   In William Faulkner’s Light In August, most characters seem isolated from each other and from society. It is often argued that Lena Grove is an exception to this, but I have found that I cannot agree with this view. Consequently, this essay will show that Lena is lonely too, and that the message in Faulkner’s work on the issue of human contact is that everyone is essentially alone, either by voluntary recession from company or by involuntary exclusion, and the only escape from this loneliness is to have a proper family to comfort you. As a child, Lena was involuntarily isolated from a society she wanted to be a part of. We are told that â€Å"six or eight times a year she went to town on Saturday† (p. 5), which obviously was not enough for her. â€Å"It was because she believed that the people who saw her and whom she passed on foot would believe that she lived in town too† (p. 5). Lena had a need to be a part of society and join the ranks of ordinary people in an ordinary town, which presumably includes marrying and starting a family. Living with McKinley in a far off mill hamlet continued to keep Lena isolated, and this condition was further aggravated by the fact that she was kept busy with housework much of the time. Admittedly, housekeeping for a large family is one kind of community, but it is not the kind that Lena wants. She would rather have a family of her own than care for someone else’s, and so she seeks love in the form of Lucas Burch. Unfortunately, Burch does not want to start a family. He only uses Lena for his own pleasure, and as soon as she tells him about the pregnancy, he leaves town (p. 16-17). Lena takes off on a quest to reunite herself with her would-be hu... ...g the society she loves. When she no longer has any hope of putting her family together the way she reckons it should be, she can no longer face society because she will never fit in. Even if she married Bunch, he would still not be her child’s father, which would make their family an anomaly. Lena has turned into a voluntary outcast, dragging Byron Bunch around to help her run her daily life but never letting him get intimate, never really making him a part of her life. After being forced into isolation from society for most of her life, Lena has now chosen to remain isolated. She is just as alone as any other character in Light in August. The conclusion I inevitably reach is that Faulkner wanted to portray family as the ultimate unit of society. Without a family, you cannot fit into society, and if you do not fit into society, you are essentially alone.   

Pros and Cons of Genetic Engineering in Plants Essay

Less tillage needed, especially with crops containing herbicide tolerance transgenes, therefore conserves fertility through minimizing soil damage through compression. |GE agriculture claims low tillage weed control: this can be achieved by ending the practice of monoculture and instead introducing proper crop rotations designed specifically to combat the weeds of the particular locality. Monoculture creates a weed paradise. | All countries face problems caused by alien species accidentally or deliberately introduced into a new environment (e.g. prickly pear in Australia). The main factor permitting this is international travel, but nobody has suggested that this should be banned. The problem of alien species is manageable, as would be the problem of genetic pollution caused by spread of seeds or pollen. As regards pollen contamination from GM varieties and the call for compensation for growers of non-GM or organic varieties whose crops are contaminated, if one is to be fair one migh t reasonably expect growers of non-GM and organic varieties to compensate growers of GM crops if they are contaminated with non-GM or organic pollen. |Genetic pollution from transgenes spreads into other organisms through pollen, seeds and microbial processes. It is fundamentally different from other forms of pollution because once the genes are out, they can’t be recalled. The best example of pollen contamination is provided by the canola seed, which was multiplied in Canada. It was officially confirmed in May 2000 that this seed was contaminated with unapproved GM canola seed and accidentally shipped to UK and other countries. By then it had been planted in Europe and large acreages of the young crop had to be destroyed. According to Advanta, the contamination occurred because of cross-pollination in Canada, where the seed was produced. The nearest source of GM contamination was 4 kilometers away.| Organic farming has long accepted accidental contamination from herbicide sp rays from neighboring farms. If there is concern about GMOs, DNA tests can be carried out.|Risks destroying organic farming, which rules out the use of GM organisms. Who will compensate organic farmers for the extra surveillance and analysis, which will be needed to ensure that the organic food chains remain free of GMOs?| The Starlink debacle is indeed a lesson that the GM food producers will learn from. Identity Preservation Systems are being put in place, verified by DNA analysis, to ensure that GM and non-GM supplies are kept separate.|The massive contamination in 2000 of the USA corn (maize) crop and human food chain by Starlink, a variety that is not approved for human consumption, shows that genetic pollution from transgenic crops to non-transgenic crops and food is inevitable. Starlink maize produces the Cry9C protein, which may be a human allergen. Two other major contaminations of ordinary seed (maize and canola seed) with GM seed have already occurred leading to emergency recalls of the product.| Reduces labor costs. |Sustainable organic agriculture creates much needed jobs in depressed rural economies.| Environmentally relatively benign herbicides are used and less of them. Opposing GM crops forces farmers to use herbicide resistant varieties which have not been made by GM such as those resistant to sulphonylurea herbicides which more readily give rise to herbicide resista nt weeds.|Promotes â€Å"agribusiness†, therefore more herbicide use. Herbicides are responsible for much illness in farm workers and contaminate drinking water.| Enhances biodiversity by allowing weeds to continue growing for longer thus providing nutrition for animals. After weed kill a mulch forms which hosts a thriving population of insects, arthropods etc.|The total herbicides used with herbicide tolerant crops kill all weeds thus reducing biodiversity in the field.| No insecticidal sprays needed on crops that have insecticidal Bacillus thuringiensis (Bt)-toxin genes engineered into them. Plants with Bt or other insecticidal genes are likely to give rise to lower levels of mycotoxins in the final food product. Less insect damage means less opportunity for fungi to infect the plant and bring toxic substances.|As with weed control, control of insect damage is achievable with properly designed crop rotation and other forms of good husbandry such as intercropping. Healthy pl ants not imbalanced by chemical fertilizers build up their own defenses against insect attack. | GM plants are carefully tested for environmental and ecological impact, including their effects on earthworms and beneficial insects. Bt crops target only insects, which attack the crop. Future insect resistance genes will be engineered to express in leaves and stem rather than in pollen and seed. There is already evidence that the Bt gene is expressed less in Bt corn pollen than in leaves/stems therefore the risk to butterflies (e.g. Monarch) through pollen drift onto their food plants (e.g. milkweed for Monarch) is diminished. |In relation to population variance, sample sizes in lab and field tests (e.g. of earthworms) are sometimes too low to detect even large effects. Insecticidal crops containing the gene for Bacillus thuringiensis (Bt)-toxin kill beneficial organisms such as bees, ladybirds, lacewings & butterflies (e.g. through pollen). The Bt plant remains falling to the ground are harmful to earthworms and other members of soil fauna. Bt toxins are secreted into soil from Bt plant roots and are toxic to lepidoptera in the soil (Stotzky, et al. Nature 402, 480 (1999)). The specific targeting and elimination of one insect pest has led to other pestiferous insect species moving into the ecological niche created by the disappearance of the first species. Getting rid of one problem simply created another. If Bt toxin transgenes spread to wild relatives of crop plants the wild plants may also develop resistance to insect herbivores. This could lead to the affected wild plants becoming invasive weeds.| The problem of resistance to Bt toxin and other toxins engineered into crops can be countered by planting suitably sized ‘refuges’ of a non-GM variety of the crop at suitable intervals within the crop. The interbreeding of the wild population with the Bt-exposed potentially resistant population will dilute out the genetic trait and thus prevent it building up.|Putting the Bt toxin gene in the crop exposes the pest to the toxin for longer, thus allowing natural genetic resistance to the toxin to develop in the pest. So-called refuge systems do not work, partly because breeding cycles in the differing pest populations are not synchronized. Refuges of up to 40% of the acreage are having to be recommended and this is not practical or popular for farmers. The build up of Bt toxin resistance threatens to render ineffective an insecticide long used by organic agriculture. Increased use of biopesticides in transgenic crops deprives the ecosystem of one of its natural pest controls thereby putting at risk its ability to restore equilibrium after being upset by abnormal conditions. | Helps solve the problem of world hunger by creating varieties which will make more efficient utilization of scarce land and give higher yields because of better pest resistance, nutrient utilization etc.|World hunger will not be solved by technological means. It is a problem of inequitable distribution of wealth and corrupt governments. Reduces yields (e.g. cotton, soybeans and sugar beet in some areas).| If herbicide resistance spreads to weed populations it can be combated with another herbicide with a different active ingredient. The ecological and agricultural threat of a GM plant is no more than a non-GM invasive (exotic) species such as kudzu or purple l oosestrife. Although improved crop yields can be engineered by genetically modifying plants, there is ecological concern over whether these plants are likely to persist in the wild in the event of dispersal from their cultivated habitat. The results of a long-term study of the performance of transgenic crops in natural habitats on four different crops (canola seed, potato, maize and sugar beet) which were grown in 12 different habitats and monitored over a period of 10 years show that in no case were the genetically modified plants found to be more invasive or more persistent than their conventional counterparts. (M. J. CRAWLEY, S. L. BROWN, R. S. HAILS, D. D. KOHN & M. REES. Biotechnology: Transgenic crops in natural habitats Nature 409, 682 – 683 (2001)  © Macmillan Publishers Ltd)|Enhances spread of herbicide resistance to wild weed populations because the necessary genes are in the pollen, which can then pollinate wild relatives of the crop plant. This could create â₠¬Ëœsuperweeds’ especially if ‘gene stacking’ of several different transgenes occurs. Spread of transgenes is also caused by birds, animals & machinery carrying the seed to other locations (e.g. canola seed on Ailsa Craig isle, 10 miles from Scottish mainland) Increased weediness of GM crops is already beginning to show. In 1999, in Alberta, Canada canola seed volunteers (unwanted crop plants coming up the following year) resistant to three different herbicides have been discovered. A series of chemical and DNA tests confirm the weeds in farmer Tony Huether’s field near Sexsmith are resistant to Roundup ®, Liberty ® and Pursuit ® herbicide chemicals. Invasive species of plants can remain relatively unproblematic in a region for many years and then suddenly take a hold so much so that they become an economically significant nuisance. For this reason, the ecological impact of GM crops will be difficult to predict in the long term, i.e. over several decades. | Most cultivars are unlikely to survive amongst wild plant populations and those with herbicide resistance that escape will have no advantage from the herbicide resistance trait unless that particular herbicide is used. Such volunteers can be controlled with other herbicides.|Transgenic herbicide resistant cultivars could escape into the wild and become problematic ‘volunteers’ in agriculture. These volunteers will require increased use of more toxic herbicides.| Is a sustainable agriculture, because it reduces chemical inputs as well as fuel inputs for farm machinery.|Unsustainable — based on greed not need. Helps chemical agriculture to proliferate. The only sustainable agriculture for the future is organic (including biodynamic & permaculture).| Quicker and more precise than traditional breeding.|Breeding takes place outside the proper c ontext, i.e. in the laboratory, therefore the crops are so weakened that they need to have the environment of the laboratory (soil sterilization, artificial fertilizers and pesticides) brought to them in the field. Transgenic lines are unstable and can lead to crop failures (e.g. GM cotton in USA).| A greater range of distinct disease-resistant varieties can be created so that the farmer has a wide choice and can plant a mixture of several varieties of the same crop in the same field to insure against disease attack. Disease resistance traits can be rapidly introduced to cultivars, e.g. rice, thus keeping ahead of the changing pattern of disease in a particular locality.|Because of the huge investment in GM crops, the necessarily increased emphasis on single high-yielding varieties reduces genetic diversity within the crop itself. This can lay the crop open to massive losses when disease strikes.| Novel drought and salt-tolerant cultivars can be created (important for Third World Co untries).|Sustainable organic plant breeding can develop novel varieties properly suited to a locality perfectly satisfactorily.| Any royalties or technology fees are more than compensated for by advantages including higher yields and easier, therefore less expensive, husbandry.|No seed saving by the farmer is permitted. The farmer has to pay royalties to the biotech company. This undermines a traditional agricultural practice and particularly threatens peasant farming in developing countries. GM crops add to the tendency of modern chemical agriculture to undermine the autonomy of farmers and turn them into tractor drivers or machine minders for large transnational corporations.| New varieties are tested for toxicity more than any crop plants have ever been in the past, therefore they are likely to be safer. Jimmy Clark, a professor of ruminant nutrition in Animal Sciences at the University of Illinois at Urbana-Champaign, reviewed the results from 23 research experiments, which wer e conducted over the past four years at universities throughout the United States, Germany and France. In each study, separate groups of chickens, dairy cows, beef cattle and sheep were fed either genetically modified corn or soybeans or traditional corn or soybean as a portion of their diet. Each experiment independently confirmed that there is no significant difference in the animals’ ability to digest the genetically modified crops and no significant difference in the weight gain, milk production, milk composition, and overall health of the animals when compared to animals fed the traditional crops. Clark concluded, â€Å"Based on safety analyses required for each crop, human consumption of milk, meat and eggs produced from animals fed genetically modified crops should be as safe as products derived from animals fed conventional crops.† Clark added that approximately 70% of the genetically modified soybeans produced in the world and 80% of the genetically modified corn produced in the United States are used as animal feed. â€Å"Since these genetically modified crops were grown beginning in 1996, they have been fed to livestock and no detrimental effects have been reported,† Clark said. (University of Illinois at Urbana-Champaign, News Release, Apr il 2001).|Increases herbicide residues in the food because the herbicide is applied later in the growing season and closer to harvest | The issue of spread of antibiotic resistance from GM crops containing antibiotic resistance marker genes is unproven. If it is a problem at all it is likely to be small compared with the induction of antibiotic resistance through profligate use of antibiotics in animal nutrition, veterinary and medical practice.|Spreads antibiotic resistance to microorganisms in the environment, and then to pathogenic bacteria.| More profit for the farmer, seed producer and biotech company shareholder.|No demonstrable benefit to the consumer. | Crops producing ‘nutraceuticals’ can be engineered, i.e. food additives that have a nutritional benefit bordering on a pharmaceutical benefit, e.g. modified edible oils. The vitamin content of plants can be enhanced by GM. Plants which previously did not contain a particular vitamin can now be made to produce lar ge amounts of it (e.g. Vitamin A ‘golden’ rice). The aim of the GM Vitamin A rice project is not to achieve ideal levels of vitamin A intake through this source but to augment the extremely low intakes which lead to blindness and death of hundreds of thousands of people a year (Prof. Dr. Ingo Potrykus, statement, February 2001). |In 1999, Deutsche Bank issued a report advising investors to avoid investing in GM crop technology (agribiotech). A balanced diet of fresh fruit & vegetables plus cereals and protein is all that is necessary. ‘Nutraceuticals’ are a sticking plaster (band aid) attempt to remedy fundamentally unhealthy diets. Existing food sources provide adequate daily intakes of vitamins provided they are eaten in sufficient amounts and the vitamins are not destroyed in the processing or cooking. Vitamin-enhanced GM plants are an unnecessary technical solution to a problem, which does not exist. Even with Vitamin A GM rice a normal daily intake of 300 gram of rice would, at best, provide 8% percent of the vitamin A needed daily.| The ‘killer genes’ of the technology protection system (‘terminator technology’) allows the seed producer’s intellectual property (patent) to be protected by a biological rather than litigious method.|No seed saving by the farmer is permitted. The farmer has to pay royalties to the biotech company. This undermines a traditional agricultural practice and particularly threatens peasant farming in developing countries.| The increased cho ice of modern high-yielding cultivars to farmers allows diversification to keep ahead of economic, climatic and plant disease trends.|The possibility of further globalization of crop varieties that GE offers through the introduction of traits necessary for introduction into new regions of the globe erodes cultural diversity – i.e. traditionally, different crops and varieties are grown by different cultures. Genetic engineering works towards global uniformity, i.e. globalization of Western/Northern culture. There used to be far greater choice of crop varieties for farmers, sometimes hundreds of varieties of a particular crop in a given region, but this diversity is falling at an alarming rate because of the industrialization of farming under pressure from the agrochemical industry. This will be accelerated by biotech agribusiness.| GE allows the creation of plants that produce vaccines, pharmaceuticals or enhanced pharmaceutical raw materials. |GE is already used to produce ph armaceuticals in microorganisms in the much safer containment conditions of biotechnology factories. It should not be taken out into the environment thus putting the environment at risk. In any case, much of the pharmaceutical production, which would be created, is designed to treat diseases caused by industrialization and urbanization, which could be better treated not by a genetic fix but by changing lifestyles and environment.| Novel food crops are tested for genetic stability (breeding true), ‘substantial equivalence’, nutritive properties, toxicity and allergenicity. It is well known that conventional breeding can introduce increased levels of natural plant toxins into a new variety or can modify its digestibility or nutritiousness. Furthermore, certain organic crops have been shown to have higher levels of toxic substances, e.g potatoes.|GE introduces unpredictable toxic or allergenic effects into food plants (e.g. Brazil nut gene in transgenic soybeans). ‘Substantial equivalence’ is a political-commercial concept rather than a scientific one. GM plants are not genetically stable. For instance, the number of copies of an inserted gene changes through later generations of the GM plant. | This technology is completely new to the insurance industry. It is natural that insurers will be cautious about it. However, when they realize that the risks are no worse than with introduced ali en species that are dealt with by conventional methods of weed control, the problem of insurance will disappear. No amount of research under containment conditions will reveal how a GM plant will behave when grown en masse in the open field.|As the degree of escape of genes from GM crops is unpredictable, they can’t be recalled once they have escaped and they could multiply in the wild, some insurance underwriters have stated that such risks are uninsurable. There should be a moratorium on experiments in the open until the safety of the GM plant is fully tested under containment conditions. | Plant pathogens need not be used in making GM plants. The genes can be blasted into plant cells using a ‘gene gun’, which fire microparticles of metal coated with the DNA of interest.|Plant pathogens such as Agrobacterium tumefaciens (literally ‘cancer causing’) are used to shuttle genes into plants and viral gene sequences such as cauliflower mosaic virus promo ter are used to make the genes express themselves once in the plant. The pathogens could recombine with their natural equivalents in the plant thus risking unpredictable outbreaks of plant disease.| Bioprospecting has gone on since very ancient times. There is no reason why an organism, which just happens to be at a particular location of the globe, should be in the sole ownership of the people living there. Agreements can be entered into in order to protect the traditional usages of indigenous peoples.|Steals genetic commons from peasant farmers and indigenous peoples (biopiracy by the rich North, e.g. neem tree & basmati rice).| Biopolymers can be produced in GM plants allowing the manufacture of biodegradeable plastics (e.g. PHBV, Biopol), which are also sustainable because they are not made from fossil fuels. |No comment|

Book Summary “The Goal” Processes and Operations

Book Summary â€Å"The Goal† Processes and Operations Key Idea The main message of the book is that the proper way to manage any operation, whether it’s a manufacturing plant or a web design shop or a clothing store, is to: 1) Identify what needs to be changed. 2) Identify what it should be changed to. 3) Identify how to execute the change. Summary This story is based around the life of Alex Rogo, Plant Manager for Uniware, which is a division of Unico. After some very upsetting customer approaches Alex’s boss, Bill Peach, is given a challenge to turn the plant around in three months. More Summary of Devil at My HeelsDue to the limited amount of time available, there are not many outside tools available such as consultants, surveys, and so on. With very few hopes, Alex foresees the inevitable until he remembers his conversation with Jonah, a physicist who Alex knew from a previous job. It is not until Alex’s job is in at risk that he decides to devour into his conversation with Jonah. During the conversation, Jonah asks him several questions to analyze his company’s situation. The conversation leads ultimately to the question, â€Å"What is the goal of any business? After rethinking his conversation, Alex realizes that the goal of any business is to make money. Furthermore, if the goal is to make money any action toward this goal is considered productive and any action not moving towards the goal is nonproductive. Alex was unsure of such a simple answer and decided to contact Jonah to continue the search for more answers. Once Alex contacts Jonah th ey define the following measurements to define the success of any plant’s production: 1) Throughout = rate that the system is used to generate money through sales.This measurement would consist of what a product would be worth when sold at market value after deducting operational expense and inventory. 2) Inventory = all the money invested in purchasing items that will be sold. This could include the remains of their machines after being used toward the investment. 3) Operational expense = all the money used to turn inventory into output. This would include such items as depreciation of a machine, lubricating oil, scraps, etc. Jonah explains to Alex that a plant that is continuously productive is considered inefficient.He further explains that continuous production will result in high absenteeism, poor quality and employee turnover. Based on this, he would need to reduce operational expense and inventory to improve throughput to demonstrate a balanced line of production. Jona h leaves him to think about the understanding of two things: what are the dependent events and statistical fluctuations in his plant. During a hiking trip with Alex’s son, he produces a game for a few of the kids to demonstrate an ideal balance line of production.He does this by setting up dependents and uses a die to measure the statistical fluctuations. At the end of the game, he concluded that the bottleneck’s speed of production is what determines the speed of the other dependents. Therefore, inventory moves very slowly because of statistical fluctuations. In the end, this is where Alex began his search inside the plant. After arriving back at work, he and the crew began their search for the bottlenecks. They identify one of the robots, NCX-10, and the heat treatment area as the source of the bottlenecks.Once identified, they began their search for solving them. After following some simple steps they significantly increased production by 12% during the first two mo nths and 20% in the third month. Based on these increases, Alex saves the plant and his got promoted to Bill Peach’s position. Besides the ongoing theme of saving the plant, there is an underlying story about Alex’s personal life. In the beginning Alex’s wife, Julie, and him are constantly arguing about Alex working late in attempts of saving the plant which flows over into not spending any time with his family.Within the first 100 pages of the book, his wife leaves him, after being exhausted of all attempts to save their marriage. However, during his search for reclaiming the plant he does the same with his marriage. I think that the author is telling the audience that there must be a balance between these two lives. It is important for both to be in harmony because eventually they will flow in and out of each environment. Lessons Learned What I enjoyed the most about this book was the layout. It consisted of telling a story about Alex in a novel form, which in cluded dialog, plot, etc.By making the book in this way it broke the specifics down for a layperson, Alex. After all, Alex represents the average person – job going down the tube and marriage shortly following it. The source of the problem the whole time was following the rules that were and are continuously engraved into us each day. What I learned about this book is that you should not let your business and processes control you and lead you. Instead, you should be constantly criticizing and reviewing your processes and not settling for any bottlenecks or sticking points.Another major theme in the novel is that the point of a business is to make money, and more specifically, to make a profit. The way to do this is not to create as much as possible, but instead to run as efficiently as possible. That might require making drastic changes to common practices, things that on paper seem like they will hurt the bottom line. For example, in the book, they discover they’re r unning their manufacturing plant at 80% capacity. That means 20% of the time, they have machines and people just sitting there doing nothing. So they tell their sales manager to get them 20% more work.He says that they can only get it from a client who wants it at below cost, so they would lose money. But Alex convinces him that they only have materials as costs, as they have people doing nothing currently who are getting paid, so their time is not an additional expense. I thought this was very interesting. Application This book would be ideal for anyone interested in simplifying ways to improving any process – whether it is manufacturing or service oriented. These back to basics principles, help break down what has become â€Å"common practice†.

The Chicago Defender was a newspaper that defended Essays

The Chicago Defender was a newspaper that defended Essays The Chicago Defender was a newspaper that defended race against violence and issues that America didn't discuss that would resolve for the African Americans. The Newspaper was founded by, Robert S. Abott on May 5, 1905(as cited in Chicago Defender). Abott started celling his newspapers for a very low price, working in a small kitchen. Since the paper was a northern newspaper he had more freedom to attack racial issues. With Abotts dramatic headlines and graphic images, he got his readers attention, and conveying the horror of lynching and raping (as cited in Chicago Defender). The newspaper was read broadly in the South. The newspapers had to be smuggled threw the south since people were trying to confiscate it and also threatened its readers (as cited in Chicago Defender). The Chicago Defender was passed from person to person in the South, with each paper sold and was read by four to five African Americans. This put its readership at over 500,000 each week. The Chicago Defender was the first African American newspaper to have a health column and have a full page of comic strips. Chicago Defenderon the black experience2 The Defender wages its most aggressive campaign during "The Great Depression" movement. During the Great Depression African Americans began to build a new place for themselves to confront economic and social changes. African Americans who left the south and made they're way to the north was a huge impact to the urban life. The South was where they were driven from out of their homes and surrounded by segregation, and the North provided African Americans more opportunities in life, such as industrial work. In many Northern cities African Americans population started to expand (as cited in Staff, H. (2010). Great Migration ). The Defender spoke on hazards on the remaining African Americans of the segregation in the South. The newspaper started using editorials, articles, and cartoons headlines to attract people to the movement. From the Defender's support of the movement, it caused black readers to migrate to the North where there were more opportunities for African Americans. T here were 1 million African Americans who had left the South by the end of 1919 (as cited in Chicago Defender). There were African Americans who traveled from boat, trains, and automobiles. Many blacks found a good outcome from moving out of the south to north, by finding jobs, in factories and slaughterhouses. Even though there were opportunities for work there was competition for housing in crowded cities (as cited in Staff, H. (2010). Great Migration ). The North lacked segregation, but there was still racism and prejudice. As years progressed, The Chicago Defender provided first hand coverage of evens such as the Red Summer Riots. There was a city of race riots in cities across the country. This riot impacted a lot Chicago Defenderon the black experience3 of deaths in the United States. In most deaths there were whites killing Africans Americans, and in some cases blacks fought back. This riot campaigned to anti-lynching legislation (as cited in Chicago Defender). Abott let his nephew John H. Sengstacke take control of The Chicgao Defender and Abott became the first president of the National Negro Publishers Association (as cited in Chicago Defender). The Chicago defender was the largest African American owned newspaper in the world. Chicago Defenderon the black experience4 References: History.com Staff, H. (2010). Great Migration. Retrieved February 02, 2017, from history.com/topics/black-history/great-migration New spapers The Chicago Defender ( n.d.). Retrieved February 02, 2017, from pbs.org/blackpress/news_bios/defender.html

Foods Role in the Evolution of the Human Jaw

Foods Role in the Evolution of the Human Jaw You may have heard the old adage that you should chew your food, especially meat, at least 32 times before you try to swallow it. While that may be overkill for some types of soft food like ice cream or even bread, chewing, or lack thereof, may have actually contributed to the reasons human jaws became smaller and why we now have smaller numbers of teeth in those jaws. What Caused the Decrease in Size of the Human Jaw? Researchers at Harvard University in the Department of Human Evolutionary Biology now believe that the decrease in size of the human jaw was, in part, directed by the fact that human ancestors began to â€Å"process† their foods before they ate them. This does not mean adding artificial colors or flavors or the type of processing of food we think of today, but rather mechanical changes to the food such as cutting meat into smaller pieces or mashing fruits, vegetables, and grains into bite sized, small jaw friendly amounts. Without the large pieces of food that needed to be chewed more times to get them to pieces that could be swallowed safely, the human ancestors’ jaws did not have to be so large. Fewer teeth are needed in modern humans compared to their predecessors. For instance, wisdom teeth are now considered vestigial structures in humans when they were necessary in many of the human ancestors. Since jaw size has considerably gotten smaller throughout the evolution of humans, there is not enough room in some people’s jaws to comfortably fit the extra set of molars. Wisdom teeth were necessary when humans’ jaws were bigger and the food needed more chewing to be fully processed before being able to be swallowed safely. The Evolution of Human Teeth Not only did the human jaw shrink in size, so did the size of our individual teeth. While our molars and even bicuspids or pre-molars are still larger and flatter than our incisors and canine teeth, they are much smaller than the molars of our ancient ancestors. Before, they were the surface upon which grains and vegetables were ground into processed pieces that could be swallowed. Once the early humans figured out how to use various food preparation tools, the processing of the food happened outside of the mouth. Instead of needing large, flat surfaces of teeth, they could use tools to mash these types of foods on tables or other surfaces. Communication and Speech While the size of the jaw and the teeth were important milestones in the evolution of humans, it created more of a change in habits besides just how many times food was chewed before swallowed. Researchers believe the smaller teeth and jaws led to changes in communication and speech patterns, may have something to do with how our body processed changes in heat, and could even have affected the evolution of the human brain in areas that controlled these other traits. The actual experiment performed at Harvard University used 34 people in different experimental groups. One set of groups dined on vegetables early humans would have had access to, while another group got to chew on some goat meat- a type of meat that would have been plentiful and easy for those early humans to hunt and eat. The first round of the experiment involved the participants chewing completely unprocessed and uncooked foods. How much force was used with each bite was measured and the participants spit back out the fully chewed meal to see how well it was processed. The next round â€Å"processed† the foods the participants would chew. This time, the food was mashed or ground up using tools the human ancestors may have been able to find or make for food preparation purposes. Finally, another round of experiments were performed by slicing and cooking the foods. The results showed that the study participants used less energy and were able to eat the processed foods much more easily than those that were left â€Å"as is† and unprocessed. Natural Selection Once these tools and food preparation methods were widespread throughout the population, natural selection found that a larger jaw with more teeth and oversized jaw muscles were unnecessary. Individuals with smaller jaws, fewer teeth, and smaller jaw muscles became more common in the population. With the energy and time saved from chewing, hunting became more prevalent and more meat was incorporated into the diet. This was important for early humans because animal meat has more calories available, so more energy was then able to be used for life functions. This study found the more processed the food, the easier it was for the participants to eat. Could this be why the mega-processed food we find today on our supermarket shelves are often high in caloric value? The ease of eating processed foods is often cited as a reason for the obesity epidemic. Perhaps our ancestors who were trying to survive by using less energy for more calories have contributed to the state of modern human sizes.

Mothers Day Etymology Where Does Mom Come From

Mothers Day Etymology Where Does Mom Come From Mother’s Day Etymology: Where Does â€Å"Mom† Come From? Today is Mother’s Day, the day we thank our female parents for their love and patience. But where do the words â€Å"mother† and â€Å"mom† come from? Why are there so many words for mothers in English? And are they all correct? Let’s take a (motherly) look and find out. The Origins of Mother The modern English â€Å"mother† comes from the Old English term modor. And â€Å"mom,† along with other of informal or shortened terms such as â€Å"mommy† and â€Å"ma,† are often traced to this root. Interestingly, though, these shorter words may be even older. The word â€Å"mama† appears in some form in dozens of languages, including Mandarin (Mma), Hindi (mÄ Ã¡ ¹Æ') and Arabic (mÄ ma). This is because simple noises like â€Å"mama† and â€Å"papa† are among most babies’ first vocalizations. We imagine â€Å"mama† means â€Å"feed me† most of the time.(Photo: amyelizabethquinn) The theory, then, is that â€Å"mother† and its modern variations are all rooted in the baby talk of â€Å"mama.† So one thing we have in common with our earliest ancestors may be our words for â€Å"mom.†   Mom, Mum or Mam? In the US, most people call their mothers â€Å"mom.† But you may have heard â€Å"mum† or â€Å"mam† used as well, especially in other countries. So why are there so many variations on this term? Largely, it’s a matter of where you come from. The three terms we’ve picked out here, for instance, are all associated with different places: Mom is most associated with American English. Mum is common in Australia and the UK (especially England). Mam is common in Ireland, Wales, and parts of northern England. These are all accepted terms for â€Å"mother† in one place or another, so your preference will usually depend on where you grew up. And the â€Å"correct† spelling will depend on the dialect in question. But in American English, you are usually safe sticking with â€Å"mom.† But which came first? Well, â€Å"mam† is probably the oldest of the three spellings above, since the earliest recorded use of â€Å"mama† in English dates back to 1707. By comparison, the earliest appearances of â€Å"mum† and â€Å"mom† are from 1823 and 1867, respectively. Whatever your chosen term, though, we hope all the mothers out there are having a great day! And, mother or not, we hope you’ve enjoyed our etymological look at motherhood.

American Dream Coursework Example | Topics and Well Written Essays - 250 words

American Dream - Coursework Example This is living a life short of imposed constraints from class, race, caste or ethnicity (Miller, 2010). The play’s protagonist, Willie Loman, would define the American Dream from a traditional perspective from referring to his childhood after observing the failures of his father. Willie Loman would describe the American dream as an understanding that it predicated upon continual acquisition and wealth of money is doomed as failure. He believed that money was incapable of availing happiness to individuals. On the contrary, Willie’s sons would define the American Dream as a self set path to success that does not necessarily depend on past failures. Willie seems to instill the values of continuity from the past occurrences and at the same time positively emphasizing the need for hard work. What Willie failed in is advising his sons to start with big success rather than telling them to start from something small and grow it into an empire (Miller, 2010). The dramatist Miller could be referring the American dream and values as an ability to prosper from mere charisma. He believes that personality, not innovation and hard work are the key to success. In reaction to the play I believe that the dramatist wanted to show that one is open to choose the path that will lead them to their version of American dream. In reference to the act, â€Å"WILLY: Biff Loman is lost. In the greatest country in the world a young man with such—personal attractiveness, gets lost. And such a hard worker. There’s one thing about Biff—he’s not lazy (Miller, 2010)." Miller attempts to discourage laziness. He is also in reference with the character’s past by saying, â€Å"Remember how they used to follow him around in high school? When he smiled at one of them their faces lit up. When he walked down the street†¦( Miller,

Brown v Board of Education Research Paper Example | Topics and Well Written Essays - 3000 words

Brown v Board of Education - Research Paper Example Thus, public schools could achieve only limited success in integration of white and black students in desegregated schools. A study involving six communities and schools reveals that educators tried to convince the middle class white parents and students for desegregation so as to prevent them from moving out which would make the public schools economically unviable. At the same time, black students were often asked to leave their community schools by offering them bus facilities and such actions resulted in the closure of those black schools. (Wells, Holmes and Revilla). The policy makers tried to bring about color blindness in toto. It was to some extent achieved as stated by the authors â€Å"†¦.when several of the districts and schools we studied had seen a great deal of racial tension and even â€Å"rioting†. By the late 70s, a degree of clam had returned; not talking about race seemed the best way to â€Å"keep the peace† and â€Å"to keep the lid on things † (Wells, Holmes and Revilla 13). Major Claim   A Prejudice and unequal treatment Although schools were desegregated and students of color and whites started attending the same public schools, the administration put the black students in separate class rooms within the same schools. Their needs were often ignored (Wells, Holmes and Revilla). African Americans are over represented in special education The Individuals with Disabilities Education Act (IDEA)3 provides for free public education to students with disabilities. This special education efforts call for initiatives on the part of schools to have appropriate procedures to ensure that a child referred for special education is actually a child with... The paper tells that the Individuals with Disabilities Education Act (IDEA) provides for free public education to students with disabilities. This special education efforts call for initiatives on the part of schools to have appropriate procedures to ensure that a child referred for special education is actually a child with disability requiring special education. It is often the case that wrong cases of children are referred for special education. It is especially the case with African American students in many districts of the country. This results in a disproportionate representation of group membership for special education. Overrepresentation in special education is said to occur when the membership of a particular group, say African Americans is found to be larger than the percentage of that group in the overall educational system or within a given disability group. Such a variance is a cause for concern (Council For Exceptional Children and Black School Education). It has been contended that disproportionate representation of African American students in special education results due to inadequate/wrong allocation of educational resources, wrongful curriculum and pedagogy, and insufficient teacher preparation. The White privilege and racism is charged with referring disproportionate number of African American students for special education categories such as mental retardation and learning disabilities. Such students once labeled as such tend to show results in achievement gains and come out of special education at rates much higher than those of their counterparts in White students with disabilities.

Killing of the Buddha Essay Example | Topics and Well Written Essays - 250 words - 187

Killing of the Buddha - Essay Example The Koan should not be taken since killing goes against Buddhist teachings. Instead, the koan advocates for self-interrogation with an aim of bringing in clarity aspects that promotes the development of one’s self. In the Koan â€Å"finding the Buddha† symbolizes a walk on the path of enlightenment. The process can be interpreted to include our path or the direction that an individual takes in his life. The â€Å"Buddha† that we are supposed to represent an idealized personal perfection that we have about ourselves. The Buddha represents us as well as our projection to the outside world. The Buddha consists of our conception of absolute enlightenment (McGee, 2015). The â€Å"Killing of the Buddha† means that human beings are often wrong in the conception of themselves. The Koan dictates that it is practical and achievable for an individual to separate himself from the misconception of himself through meditation. If a person believes that he has spiritual e nlightenment, then the person must get rid of the perception and meditate. Through meditation, the enlightenment has no permanence, and everything keeps on changing. The Koan teaches us that if we consider ourselves as having all solutions then such a perception must be avoided, and we must question such solutions to get better solutions. By following the Koan and always meditating, then one creates a learning process and keeps on enlightening. Such a process reinforces the journey to being complete. Ultimately, one learns that he or she is a disguised Buddha (McGee, 2015).

Family Systems Theory Research Paper Example | Topics and Well Written Essays - 1750 words

Family Systems Theory - Research Paper Example Miller’s living systems theory also is considered for its structural elements, as it implements largely scale life systems than Bronfenbrenner’s model. Finally, Bowen’s theory is considered as it further incorporates interlocking elements into the analysis of family systems. Abstract – Depth Depth is examined in relation in relation to Bertalanffy, Bronfenbrenner, Bowen and Miller’s family systems theories. Bertalanffy’s system perspective is considered as it advances notions of family systems as necessarily embodying concerns related to interactivity. Bronfenbrenner’s ecological system is considered as it implements specific life systems, notably the microsystem, mesosystem, and exosystem. Miller’s living systems model implements both specific elements, but also expands to include all living things. This is notable as it implements more foundational considerations than Bronfenbrenner’s approach, allowing for increased re cognition of the family system. Bowen’s approach expands depth considerations through the implementation of a variety of family system investigative tools, including investigations into differentiation of self, the nuclear family emotional system, and triangles. Abstract -- Application Bertalanffy, Bronfenbrenner, Bowen and Miller’s family systems theories are considered in terms of specific applications. ... Through the foundational elements this model incorporates this perspective is applied in establishing the base elements of the system. Bowen’s approach is similarly applied in terms of its emphasis on interlocking concepts. While all of the aforementioned system components implements differing perspectives, it’s recognized that their comprehensive application will reveal different results. The interstices of these results then can be considered as revealing more thorough insights than a singular approach could provide. Family Systems Theory While childhood development and human psychology have long been prominent scholarly considerations, the 20th century witnessed a decided shift in investigative emphasis. Within this spectrum of understanding, an increasing emphasis on the nature of environment or systems as contributing to psychological and developmental concerns emerged. Past theories were largely been rooted in mechanistic or atomistic accounts of psychology; these were largely abandoned for the more holistic perspectives inherent in systems models. This research considers four prominent perspectives on systems theory. Specifically, notions proposed by Bertalanffy, Bronfenbrenner, Bowen and Miller are examined within the context of family systems theory. Ludwig Von Bertalanffy was one of the original theorists to consider the importance of systems within science. While his perspectives would later be adopted in terms of psychology and families, his perspectives spanned throughout science. Referred to as General Systems Theory, this perspective shifted scientific analysis of organisms from a mechanistic model, to one that emphasizes more holistic environmental concerns. While the mechanistic approach greatly situated investigation in-terms of

Dividend announcements and share prices Essay Example | Topics and Well Written Essays - 2000 words

Dividend announcements and share prices - Essay Example The term signaling is commonly used in economic analyses. It refers to "the idea that one party (termed the agent) conveys some meaningful information about itself to another party (the principal)." ("Signaling", 2006) Also, signaling is based on the principles of asymmetric information. This says that, "In some economic transactions, inequalities in access to information upset the normal market for the exchange of goods and services." ("Signaling", 2006) In such a situation the signaling hypothesis says that, two parties could get around the problem of asymmetric information by having one party send a signal that would reveal some piece of relevant information to the other party. As mentioned, dividend announcements are one way by which information is conveyed to investors as well as to the market. The information content of dividend announcements has long been explored by various researchers and analysts. Moreover, various studies have been conducted to determine how dividend announcements affect the price of the shares of the company in the market. Different theories have been created to explain how certain factors affect the information content of dividend announcements and how effect that such information may have on the stock prices. The subject of the information content of dividend announcements warrants research for it affects several parties. For one, investors and shareholders are directly influenced by the stock prices of shares. Also, previous research has suggested that when dividend announcements are made, abnormal returns are seen especially during the period surrounding the announcement. (Starks, 2004) In this paper, one area of dividend announcements will be explored. Particular focus will be given on the size effect or the effect of the size of the firm on the abnormal returns that are seen when dividend announcements are made. This research will concentrate on the size effect as made evident in the Australian stock market. By conducting such analysis, this research will be able to answer the following research question: What is the effect of dividend announcements on asset prices Theoretical Framework This research will follow the methodology utilized by Mozes and Rapaccioli (1995). Their study aimed to determine the role of dividends in explaining the size effect. The said study is a follow up on past researchers that have been conducted wherein it was discovered that, on average, the firm's security price increases around its announcement of an increase in dividends or a special dividend. Moreover, previous researches have shown that the converse likewise holds. This means that a firm's security prices tens to decrease when an announcement of a decrease in dividends or a discontinued dividend is made. Also, past studies have shown that reactions to dividend changes are greater for small firms than for large firms. Using empirical analysis, the study of Mozes and Rapaccioli (1995) aimed to investigate "the extent to which dividend announcements affect the relation between firm size and the amount of information provided by earnings announcements." However, since this research does not concern itself with earnings announce

Summary hardware, software findings Research Paper

Summary hardware, software findings - Research Paper Example This is a special information system that is procured differently from the rest of the software. This information system, however, is not fully owned by the Intel Corp company. This is because it is hired from the cloud service provider (Blundell, 2008). Another important feature of the architecture of hardware and software of Intel Corp is that it has adopted the latest technologies in their system. There is the use of cloud computing in their network. This technology helps to overcome the challenges of having servers and whole applications on the local site. This system and arrangement are seen in the way the company operates the CRM software. The CRM software is accessed from the cloud service provider. This means that the company does not own the software system in full (Hamlet, 2010). Another important aspect that can be seen in the software is that of using one vendor to procure the software. Most computers are installed with Windows Operating systems and Windows based software applications, like office suites and utility programs. The hardware components that are found in the company are seen to adopt client-server architecture in most of the structures that have been analyzed and presented so far. Most of the computer hardware is structured in such a way that the machines depend on each other to access the important server parts of the hardware. One deficiency that I find with the software is that they are from one vendor. As stated earlier, most of the applications are for Windows. In case there will be a need to have an upgrade so that there other applications from the other vendors, this could be a tedious and difficult task. This is because there is no arrangement that has been done to ensure that the future installations of different applications are well taken care of. Another deficiency is that of efficient

Dividend announcements and share prices Essay Example | Topics and Well Written Essays - 2000 words

Dividend announcements and share prices - Essay Example The term signaling is commonly used in economic analyses. It refers to "the idea that one party (termed the agent) conveys some meaningful information about itself to another party (the principal)." ("Signaling", 2006) Also, signaling is based on the principles of asymmetric information. This says that, "In some economic transactions, inequalities in access to information upset the normal market for the exchange of goods and services." ("Signaling", 2006) In such a situation the signaling hypothesis says that, two parties could get around the problem of asymmetric information by having one party send a signal that would reveal some piece of relevant information to the other party. As mentioned, dividend announcements are one way by which information is conveyed to investors as well as to the market. The information content of dividend announcements has long been explored by various researchers and analysts. Moreover, various studies have been conducted to determine how dividend announcements affect the price of the shares of the company in the market. Different theories have been created to explain how certain factors affect the information content of dividend announcements and how effect that such information may have on the stock prices. The subject of the information content of dividend announcements warrants research for it affects several parties. For one, investors and shareholders are directly influenced by the stock prices of shares. Also, previous research has suggested that when dividend announcements are made, abnormal returns are seen especially during the period surrounding the announcement. (Starks, 2004) In this paper, one area of dividend announcements will be explored. Particular focus will be given on the size effect or the effect of the size of the firm on the abnormal returns that are seen when dividend announcements are made. This research will concentrate on the size effect as made evident in the Australian stock market. By conducting such analysis, this research will be able to answer the following research question: What is the effect of dividend announcements on asset prices Theoretical Framework This research will follow the methodology utilized by Mozes and Rapaccioli (1995). Their study aimed to determine the role of dividends in explaining the size effect. The said study is a follow up on past researchers that have been conducted wherein it was discovered that, on average, the firm's security price increases around its announcement of an increase in dividends or a special dividend. Moreover, previous researches have shown that the converse likewise holds. This means that a firm's security prices tens to decrease when an announcement of a decrease in dividends or a discontinued dividend is made. Also, past studies have shown that reactions to dividend changes are greater for small firms than for large firms. Using empirical analysis, the study of Mozes and Rapaccioli (1995) aimed to investigate "the extent to which dividend announcements affect the relation between firm size and the amount of information provided by earnings announcements." However, since this research does not concern itself with earnings announce

Credit Cards vs Debit Cards Essay Example | Topics and Well Written Essays - 1000 words

Credit Cards vs Debit Cards - Essay Example Paying the credit card expenses within the billing period offers the user an opportunity to pay the money without interest. The disadvantage is that the interests pile up rapidly in case the money spent is not paid within the billing period. When used responsibly, credit cards can be of great help as they help the user build credit, which can eventually result in rewards and gifts. This paper focuses on effects that credit and debit cards has, how it can put you far in debt and how it impacts your credit. The advantage of having a debit card is that you can use it to shop in various places all over the world. Additionally, most ATM cards are pre-set such that they can provide debit option thus there is no need for cardholders to carry money around. On the other hand, credit card use entails purchasing good after which you sign or provide you credit card pin number as an assurance that you will pay the debt later (Nelson, Nelson, & Stroup, 2012). Most people prefer using debit cards t o credit card arguing that using debit cards prevents one from over expenditure since it makes one feel like you are using cash payments. The fact that debit cards are connected to a checking account enables the users limit purchases and only buys items that they can afford to pay for at the moment. Additionally, most establishments that offer debit cards do not have any charges for any transactions. On the other hand, credit cards holders have to pay quite a high interest if they fail to pay the bills in time in addition to card charges (Nelson, Nelson, & Stroup, 2012; Carbo-Valverde, et al., 2007). An advantage that credit cards have over debit card is that payments for goods purchased using credit card can be withheld till the buyer is satisfied that the quality of the product is satisfactory. On the contrary, sellers make instant deductions for goods purchased using debit cards. The Fair Credit Billing Act supports such action since it posits that the purchaser has no liability for fraudulent transactions and for goods, whose quality is unsatisfactory or undelivered services. This applies for any disputable purchases. This gives credit card holders protection against deceitful merchants or service providers or in case of theft (Basel, 2006). One disadvantage of being a debit cardholder is that, in case of debit card theft, you may have to pay for all purchase transactions done using your card, which may include overdrafts particularly if you fail to realize and notify your bank in a period of 60 days. Debit cards thus have restricted consumer protection as compared to credit cards. While doing online or over the phone purchases, credit cards are the preferable option since they offer protection to the user thus helps take care of any misadventure (Directgov, 2012), Credit card users have an opportunity to build a proper credit by ensuring punctual bill payment. Good credit history is important and can help in securing loans, insurance, or in getting a job. Loans borrowed by individuals with a good credit history have a lower interest rate as compared to those for persons with unsuitable or no credit history. Additionally, some credit card offer incentives that card holders can use to obtain gifts as well as get discounts (Barrett, 2009). Debit cards provide for overdrafts, which must be made at a specified period. However, it is advantageous in that the interest rates for such

Experiment on Changes in Serum Levels of Irisin

Experiment on Changes in Serum Levels of Irisin Khaled Abdelfattah Abdelhamid Abulfadle, MD   Serum irisin level changes after propylthiouracil treatment of L-thyroxine induced hyperthyroidism in rats ABSTRACT Background: Thyroid hormones play an essential role in lipid, protein and carbohydrate metabolism; and they regulate thermogenesis and basal metabolic rate. Irisin is a myokine that is secreted as a product of fibronectin type III domain containing 5 (FNDC5) was shown to be present in many tissues, including the thyroid tissue. Objective: To investigate the possible changes in serum levels of irisin that occurred in a rat model of hyperthyroidism and the effects of use of propylthiouracil (PTU) in its treatment. Design: 18 male albino rats were divided into 3 groups. Group I was the intact control. Rats of group II and III received daily 0.3 mg/kg subcutaneous injection of L-thyroxine (LT4) for 12 consecutive days. On the thirteenth day, animals of group III (Hyperthyroid PTU treated) received 5 ml/kg i.p. injection of propylthiouracil (PTU) along with an equivalent amount of LT4 as administered to group II animals for more 15 days. Animals of group II (Hyperthyroid control) continued to receive LT4. On the day of termination (28th day of starting LT4 treatment), overnight (12hrs) fasted animals were sacrificed by decapitation under ether anesthesia. Results: In the hyperthyroid control group, there was a significant decrease in serum level of TSH (P0.05) in serum levels of TSH, T4, T3 irisin, and, BMI in hyperthyroid PTU group in comparison to that in the intact control group. In the hyperthyroid control group, there was a significant increase in the serum level of both glucose (P0.05) in the hyperthyroid PTU treated group in comparison to that in the intact control group. In the hyperthyroid control group, there was a significant decrease in serum levels of both TC (P0.05) in serum levels of both TG and LDL-C in comparison to that in the intact control group. Conclusion: This study showed a significant increase in serum levels of irisin in L-thyroxine induced hyperthyroidism in rats. On using PTU, serum levels of irisin, thyroid hormones, metabolic parameters and BMI were significantly changed in comparison to the hyperthyroid control group. Keywords: Irisin, T3, T4, TSH, Propylthiouracil, Hyperthyroidism. Introduction: Irisin is a myokine that is secreted as a product of fibronectin type III domain containing 5 (FNDC5) in the skeletal muscle (Samy, Ismail et al. 2015, Jin Zhang 2017, Nathan C. Winn 2017). FNDC5, which is the precursor of irisin was shown to be present in many tissues, including the thyroid tissue (Huh, Panagiotou et al. 2012). It is secreted by a peroxisome proliferator-activated receptor ÃŽÂ ³ (PPARÃŽÂ ³) coactivator 1ÃŽÂ ± (PGC1-ÃŽÂ ±) after an exercise (Aydin 2014). Irisin was found to have an anti-obesity effect as it replaces the white fatty tissue with brown fatty tissue by the increase of uncoupling protein-1 (UCP1) resulting in oxygen consumption and stimulation of thermogenesis (Bostrà ¶m, Wu et al. 2012, Castillo-Quan 2012, Roca-Rivada, Castelao et al. 2013, Jin Zhang 2017, Nathan C. Winn 2017). Stengel, Hofmann et al. (2013) found that irisin level was identified to be high in obesity and to be low in anorexia nervosa. On the other hand, thyroid hormones pla y an essential role in lipid, protein and carbohydrate metabolism; and they regulate thermogenesis and basal metabolic rate (Hulbert 2000). Also, hyperfunction of thyroid gland is a common endocrine disorder which is accompanied by metabolic imbalance, oxidative stress and abnormal energy homeostasis (Erdamar, Demirci et al. 2008). There were some controversies in the results of studying the effect of thyroid hormone level changes on serum levels of irisin as Yalcin, Akturk et al. (2016) found an increase in serum irisin levels in hyperthyroidism and they suggested that it might contribute to altered energy metabolism. Also, Samy, Ismail et al. (2015) stated that hyperthyroidism was associated with up-regulation of serum irisin in male rats, probably as a response to myopathy and/or oxidative damage observed in both conditions. Moreover, Ruchala, Zybek et al. (2014) reported a borderline elevation of serum irisin in hyperthyroid versus hypothyroid patients. On the contrary, Panagiot ou, Pazaitou-Panayiotou et al. (2016) stated that changes in thyroid hormone levels did not affect circulating irisin levels in humans. Also, Stengel, Hofmann et al. (2013), Ellefsen, Vikmoen et al. (2014) and Gouni-Berthold, Berthold et al. (2013) reported lack of associations between levels of irisin, TSH and/or thyroid hormones. On the other hand, Zybek-Kocik, Sawicka-Gutaj et al. (2016) stated that irisin concentration was changed during prolonged thyroid function impairment. Also, AteÃ…Å ¸, Altay et al. (2016) found that, in hypothyroidism, there was a positive correlation between serum irisin levels and thyroid stimulating hormone (TSH) while a negative correlation was found between irisin levels and thyroxine (T4). Thus, this study was conducted to investigate the possible changes in serum levels of irisin that occurred in a rat model of hyperthyroidism and the effects of use of propylthiouracil (PTU) in its treatment. Materials and Methods: Animals preparations and experimental protocol: In the Department of Physiology, Faculty of Medicine, Zagazig University, this experimental study was done from 6th of November 2016 to 28th of December 2016. 18 adult male albino rats, age and weight matched (170-195 gm), were purchased from the animal house of Zagazig University and were housed at 20-22 °C on a 12-h light-dark cycle and for 5 days, to achieve acclimatization, they were supplied with tap water and a standard chow diet. Rats were divided into 3 groups of 6 each. Group I animals served as the intact control, whereas those of group II and III received daily subcutaneous injection of L-thyroxine (LT4) (Sigma, MO, USA) at a dose of 0.3 mg/kg for 12 consecutive days (Panda and Kar 2007). On the thirteenth day, animals of group III received propylthiouracil (PTU) (Sigma, MO, USA) 10 mg/kg intraperitoneally (Panda and Kar 2007) along with an equivalent amount of LT4 as administered to group II animals. PTU was intraperitoneally (i.p.) injected, in a volume of 5 ml/kg, dis solved in saline (Kim, Kim et al. 2012). Experiment was continued for more 15 consecutive days (from 13th LT4 treatment). Animals of group II continued to receive LT4 and acted as hyperthyroid control. Intact control rats were injected with 5 ml/kg/day subcutaneously with saline. On the day of termination (28th day of starting LT4 treatment), overnight (12hrs) fasted animals were sacrificed by decapitation under ether anesthesia. Blood from each animal was collected and by its centrifugation at 3000 rpm for 15 minutes, serum was separated and stored -20oc till the time of assay of different biochemical parameters (Kumar, Kar et al. 2014). PTU was used to treat hyperthyroidism by decreasing the amount of thyroid hormone produced by the thyroid gland (Nakamura, Noh et al. 2007), and it also inhibited the enzyme 5-deiodinase, which converts thyroxine (T4) to the active form triiodothyronine (T3) (Bahn, Burch et al. 2009). Also, it inhibited LT4-induced hyperthyroidisms in rats (Panda a nd Kar 2007). Body mass index (BMI) changes: BMI in gm/cm2 was calculated in the different groups, just before rats were sacrificed (under ether anesthesia), by dividing Body weight (gm) on Length2 (cm2) (Novelli, Diniz et al. 2007). A graduated (in centimeters) metal ruler was used for measuring the rat length by putting the zero end at the rat anus and recorded the reading which reached by the nose. BMI was used as a measure for the change in body weight of rats (Novelli, Diniz et al. 2007). Figure-1: Experimental design. Rats were divided into 3 groups. Group I was the intact control. Rats of group II and III received daily subcutaneous injection of levothyroxine (LT4) for 12 consecutive days. On the thirteenth day, animals of group III (Hyperthyroid PTU treated) received i.p. injection of propylthiouracil (PTU) along with an equivalent amount of LT4 as administered to group II animals for more 15 days. Animals of group II (Hyperthyroid control) continued to receive LT4. On the day of termination (28th day of starting LT4 treatment), overnight (12hrs) fasted animals were sacrificed by decapitation under ether anesthesia. Measurement of serum parameters: Serum level of irisin was estimated (in ng/ml) using an irisin rat ELISA assay kit following the manufacturers instructions (Catalog# EK-067-52; Phoenix Pharmaceuticals Inc., Burlingame, California, USA) with a detection range of 0.1-1000 ng/ml. Quantitative immunoassaying of T3, T4 and TSH using commercially available kits as recommended by the manufacturer (cat#SE120091, SE120090, SE120135, ELISA Kits, Sigma-Aldrich). Both serum levels of total cholesterol (TC) and triglycerides (TG) were estimated using enzymatic colorimetric methods. Serum high density lipoprotein-cholesterol (HDL-C) was assayed using NS Biotec HDL-precipitating reagent. Serum low density lipoprotein-cholesterol (LDL-C) was calculated using the Friedewald formula: LDL-C (mg/dl) = [(TC) (HDL-C) ( (Friedewald, Levy et al. 1972) Estimation of both serum glucose levels, using an automated analyzer (YSI 2300; YSI Life Sciences, Yellow Springs, OH), and serum insulin levels, using ELISA kits (RD Systems, Minneapolis, MN), were done. For assessing insulin resistance (IR), the homeostasis model assessment-IR (HOMA-IR) index was calculated by: HOMA-IR = (Nayak, Hillemane et al. 2014). There is a direct relation between insulin resistance and the value of HOMA-IR (Bonora, Targher et al. 2000). Statistical analysis: By the use of IBM SPSS Statistics for windows package version (24), data were analyzed and described as Mean ± SEM. For calculation of the statistical significance, One-way ANOVA and Tukey HSD post hoc test for multiple group comparison were used. P†°Ã‚ ¤0.05 indicated significance. Results: Table-1: Changes in serum levels of TSH, T4, T3 irisin, and, BMI among different groups Intact control Hyperthyroid control Hyperthyroid PTU treated TSH (à ¯Ã‚ Ã‚ ­IU/L) 2.82 ±0.12 0.81 ±0.05a 2.68 ±0.14bc T4 (à ¯Ã‚ Ã‚ ­g/dl) 5.33 ±0.14 16.2 ±0.2a 5.36 ±0.18bc T3 (ng/ml) 1.29 ±0.04 3.52 ±0.11a 1.36 ±0.04bc Irisin (ng/ml) 401.67 ±5.65 599.17 ±6.82a 409.5 ±6bc BMI (gm/cm2) 0.54 ±0.01 0.44 ±0.01a 0.51 ±0.01bc Data was expressed as Mean ±SEM. a P0.05 in comparison to the intact control group. c P Table-2: Changes in metabolic parameters among different groups Intact control Hyperthyroid control Hyperthyroid PTU treated Glucose (mg/dl) 91.5 ±0.92 113 ±2.33a 91.33 ±1.2bc Insulin (à ¯Ã‚ Ã‚ ­IU/ml) 2.95 ±0.12 4.86 ±0.16a 2.88 ±0.13bc HOMA-IR 0.67 ±0.02 1.36 ±0.05a 0.65 ±0.03bc TC (mg/dl) 106.5 ±2.51 89.83 ±2.52a 103.33 ±1.63bd TG (mg/dl) 55.17 ±1.22 52.33 ±0.67b 53.17 ±0.95be HDL-C (mg/dl) 54 ±1.15 43.33 ±0.88a 51.33 ±0.99bc LDL-C (mg/dl) 41.47 ±3.27 36.03 ±3.07b 41.37 ±1.92be Data was expressed as Mean ±SEM. a P0.05 in comparison to the intact control group. c P0.05 in comparison to the hyperthyroid control group. HOMA-IR, homeostasis model assessment of insulin resistance index; TC, total cholesterol; TG, triglycerides; HDL-C, high density lipoprotein-cholesterol; LDL-C, low density lipoprotein-cholesterol. Figure-2: Correlations between serum irisin levels and: TSH, T4 T3 in, the intact control group (A), hyperthyroid control group (B) and hyperthyroid PTU treated group (C); glucose in the intact control group (D); insulin HOMA-IR in the intact control group (E); glucose in the hyperthyroid control group (F); insulin HOMA-IR in the hyperthyroid PTU treated group (G); TC HDL-C in the hyperthyroid control group (H). r is the correlation coefficient. Table-1 showed changes in serum levels of TSH, T4, T3 irisin, and, BMI among different groups. In the hyperthyroid control group, there was a significant decrease in serum level of TSH (0.81 ±0.05, P group (2.82 ±0.12), (0.54 ±0.01) (5.33 ±0.14), (1.29 ±0.04) and (401.67 ±5.65) respectively. On the other hand, there were insignificant changes (P>0.05) in serum levels of TSH, T4, T3 irisin, and, BMI in hyperthyroid PTU group in comparison to that in the intact control group. Also, there was a significant increase in both serum level of TSH (2.68 ±0.14, P0.05) in the hyperthyroid PTU treated group in comparison to that in the intact control group. Moreover, there was a significant decrease in the serum levels of both glucose (91.33 ±1.2, P0.05) in serum levels of both TG (52.33 ±0.67) and LDL-C (36.03 ±3.07) in comparison to that in the intact control group (106.5 ±2.51), (54 ±1.15), (55.17 ±1.22) and (41.47 ±3.27) respectively. In the hyperthyroid PTU treated group, there was a significant increase in serum levels of both TC (103.33 ±1.63, P0.05) in serum levels of both TG (53.17 ±0.95) and LDL-C (41.37 ±1.92) in comparison to that in the intact co ntrol group (89.83 ±2.52), (43.33 ±0.88), (52.33 ±0.67) and (36.03 ±3.07) respectively. Also, there were no significant changes (P>0.05) in serum levels of TC, TG, HDL-C and LDL-C in the hyperthyroid PTU treated group in comparison to that in the intact control group. Figure-2A showed a significant positive correlation between serum irisin levels and that of T4 (r=0.97, P Discussion: This study was done to declare changes in irisin serum levels in a rat model of hyperthyroidism and the effect of PTU therapy on it. Also, to identify the association between serum irisin level changes in such conditions and some metabolic parameters including insulin resistance and lipid profile. The results of this study showed a significant decrease in serum level of TSH and BMI, but, a significant increase in serum levels of T4, T3, and irisin in the hyperthyroid control group, in comparison to that in the intact control group. Also, there was a significant positive correlation between serum irisin levels and that of T4 T3 but a significant negative correlation with serum TSH in the hyperthyroid control group. These results were supported by Huh, Panagiotou et al. (2012) who stated that FNDC5, irisin precursor, was present in the thyroid tissue. Also, the present study results were supported by Irrcher, Adhihetty et al. (2003), Ruchala, Zybek et al. (2014), Sanchis-Gomar and Per ez-Quilis (2014), Samy, Ismail et al. (2015) and Yalcin, Akturk et al. (2016) who found an increase in serum irisin levels in hyperthyroidism and they suggested that it might contribute to altered energy metabolism. Moreover, Irrcher, Adhihetty et al. (2003) reported that T3 increased the irisin precursor, PGC-1ÃŽÂ ±, expression in muscle. Furthermore, Sanchis-Gomar and Perez-Quilis (2014) stated that serum irisin was increased in hyperthyroidism as a compensatory response to oxidative stress as it had an antioxidant effect. On the contrary, Gouni-Berthold, Berthold et al. (2013), Stengel, Hofmann et al. (2013) and Panagiotou, Pazaitou-Panayiotou et al. (2016) stated that changes in levels of thyroid hormones did not affect circulating irisin levels in humans. This discrepancy between their results and that of this study could be explained by species difference. Regarding the negative correlation between both irisin and TSH hormones which was present in this study, it was support ed by Ruchala, Zybek et al. (2014). On the contrary, Stengel, Hofmann et al. (2013) and Ellefsen, Vikmoen et al. (2014) reported lack of correlation between serum levels of irisin and that of TSH and thyroid hormones. Regarding body weight changes with hyperthyroidism, the result of this study was supported by Janson, Karlsson et al. (1995), Voldstedlund, Tranum-Jensen et al. (1995) and Loeb (1996) who found a decrease in body weight with hyperthyroidism. Also, this study results were supported by Bostrà ¶m, Wu et al. (2012), Castillo-Quan (2012) and Roca-Rivada, Castelao et al. (2013) who found that irisin had an anti-obesity effect as it replaced the white adipose tissue with brown adipose tissue and increased oxygen consumption and thermogenesis. On the contrary, Stengel, Hofmann et al. (2013) and Saleh, et al. (2014) found that irisin level was high in obesity and low in anorexia nervosa. This discrepancy between their results and that of this study can be explained by species difference. On the other hand, this study results showed insignificant changes in serum levels of TSH, T4, T3 irisin, and, BMI in hyperthyroid PTU group in comparison to that in the intact control group. This indicated the improvement that occurred with PTU therapy in cases of hyperthyroidism which was supported by Nakamura, Noh et al. (2007), Panda and Kar (2007) and Bahn, Burch et al. (2009). Also, the results of this study showed a significant increase in both serum level of TSH and BMI, but, a significant decrease in serum levels of T4, T3, and irisin in the hyperthyroid PTU treated group in comparison to that in the hyperthyroid control group. These results were supported by Park, Lee et al. (2016) who found that PTU administration ameliorated hyperthyroidism, reducing T4 and T3, and, increasing both TSH and BMI. Moreover, the results of this study showed a significant increase in the serum level of both glucose and insulin, and, the value of HOMA-IR in the hyperthyroid contro l group in comparison to that of the intact control group. Also, there was a significant positive correlation between serum irisin levels and that of glucose in the hyperthyroid control group. These results indicated occurrence of insulin resistance with hyperthyroidism which was supported by Loeb (1996). This was supported also by Saleh, et al. (2014) who stated that hyperglycemia gradually up regulated FNDC5/irisin expression in the skeletal muscles non-diabetic persons. Also, this study results were supported by Hee Park, Zaichenko et al. (2013), Liu, Wong et al. (2013) and Mehrabian, Taheri et al. (2016) who found a positive correlation between serum irisin and that of glucose. On the contrary, Mehrabian, Taheri et al. (2016) found that serum irisin was negatively correlated with serum glucose level. Opposite to the results of this study, Huh, Panagiotou et al. (2012), Choi, Kim et al. (2013) and Sanchis-Gomar and Perez-Quilis (2014) found that decreased blood irisin level was a ccompanied by insulin resistance development. Sanchis-Gomar and Perez-Quilis (2014) stated also, that irisin ameliorated insulin resistance by increasing betatrophin hormone expression which stimulated ÃŽÂ ²-cell regeneration. Furthermore, the results of this study showed no significant changes in the serum level of both glucose and insulin, and, the value of HOMA-IR in the hyperthyroid PTU treated group in comparison to that in the intact control group. Also, there was a significant decrease in the serum levels of both glucose and insulin, and, the value of HOMA-IR in the hyperthyroid PTU treated group in comparison to that of the hyperthyroid control group which means improvement of insulin resistance with PTU treatment. On the other hand, Huh, Panagiotou et al. (2012) found that exposure to high blood glucose for a long time was associated with a significant decrease in irisin serum level. The discrepancy between their results and the result of this study could be explained by the difference in species and duration of the study. In the hyperthyroid control group, there was a significant decrease in serum levels of both TC and HDL-C but, there were insignificant changes in serum levels of both TG and LDL-C in comparison to that in the intact control group. Also, there were significant negative correlations between serum irisin levels and that of both TC and HDL-C in the hyperthyroid control group. On the other hand, in the hyperthyroid PTU treated group, there was a significant increase in serum levels of both TC and HDL-C but, there were insignificant changes in serum levels of both TG and LDL-C in comparison to that in the intact control group. Also, there were no significant changes in serum levels of TC, TG, HDL-C and LDL-C in the hyperthyroid PTU treated group in comparison to that in the intact control group. The results of this study was partly supported by Mehrabian, Taheri et al. (2016) found a negative correlation between irisin and TC but, a po sitive correlation with HDL-C in normal weight obesity. On the other hand, Liu, Wong et al. (2013) found a positive correlation between serum irisin level and TC in non- obese, non- diabetic persons. Also, Sanchis-Gomar, Alis et al. (2014) reported insignificant correlation between irisin and TC. Conclusion   Ã‚   This study showed a significant increase in serum levels of irisin in L-thyroxine induced hyperthyroidism in rats and this could be related to changes in thyroid hormones, body weight and metabolic parameters. On using PTU, serum levels of irisin, thyroid hormones, metabolic parameters and BMI were significantly changed in comparison to the hyperthyroid control group and insignificantly changed in comparison to the intact control group which confirmed the improvement of the hyperthyroidism. Future studies are needed to confirm these results and to ensure the possible use of irisin as a biomarker for proper treatment of hyperthyroidism.

Panama Canal Essay -- American History

In 1885, due to the tremendous problems encountered in trying to excavate a sea-level canal, the plan was changed to include a single, temporary lock and other adjustments in order to speed up the availability of the canal for traffic. Still, it was of no use : in 1889, Lesseps' company was liquidated in order to pay back investors and banks from which the company had borrowed. The appraisal of the company's belongings - including equipment, maps, and the value of the land already excavated - was very high, and in 1894, a new company, the Compagnie Nouvelle du Canal de Panama, was created in France to attempt to finish the canal. All involved thought of this as an impossible feat by the French, and ideas ran strong to sell the canal zone - possibly to the United States. France resented the loss of millions of francs (the estimated cost of the company's pursuit of the canal, including publicity and possibly a little bribery, is almost 1.5 billion francs), and subsequent trials of the heads of Lesseps' company, including Lesseps himself, began in 1893. Lesseps was condemned by the court, but never fined nor jailed. Charles de Lesseps, Ferdinand's son, and others were eventually charged with bribery, only one being sent to prison. Charles was forced to pay the fine of another defendant, but could not raise the money so fled to London until his government accepted a partial payment, nearly 5 years later. France had determined that she could not possibly complete the canal. With a lease on land in Colombia until 1903, the search was on for a buyer. Eventually, France found a friend in the United States of America. At the time, a canal in the Latin American isthmus was not a new idea to America, either. In 1887, the government sent ... ...he Hay-Bunau-Varilla treaty - which was ratified by the new Panamanian Government in 1903, and by the American Senate in early 1904. Before any work could begin, the most deadly of the problems on the isthmus had to be overcome - disease. The government wasn't going to allow mortality rates like had been seen during the French reign - somewhere between ten and twenty thousand were estimated to have died at the canal zone between 1882 and 1888. For this purpose, American doctor William Gorgas was called to examine the area. The most troublesome diseases were the mosquito-carried malaria and yellow fever - the same diseases that had kept Napoleon Bonaparte from putting down the uprising in Hati in 1801 - but almost all diseases known to man were endemic. Tuberculosis, cholera, diphtheria, smallpox, bubonic plague - all were cases on file at Panama hospitals in 1904. Panama Canal Essay -- American History In 1885, due to the tremendous problems encountered in trying to excavate a sea-level canal, the plan was changed to include a single, temporary lock and other adjustments in order to speed up the availability of the canal for traffic. Still, it was of no use : in 1889, Lesseps' company was liquidated in order to pay back investors and banks from which the company had borrowed. The appraisal of the company's belongings - including equipment, maps, and the value of the land already excavated - was very high, and in 1894, a new company, the Compagnie Nouvelle du Canal de Panama, was created in France to attempt to finish the canal. All involved thought of this as an impossible feat by the French, and ideas ran strong to sell the canal zone - possibly to the United States. France resented the loss of millions of francs (the estimated cost of the company's pursuit of the canal, including publicity and possibly a little bribery, is almost 1.5 billion francs), and subsequent trials of the heads of Lesseps' company, including Lesseps himself, began in 1893. Lesseps was condemned by the court, but never fined nor jailed. Charles de Lesseps, Ferdinand's son, and others were eventually charged with bribery, only one being sent to prison. Charles was forced to pay the fine of another defendant, but could not raise the money so fled to London until his government accepted a partial payment, nearly 5 years later. France had determined that she could not possibly complete the canal. With a lease on land in Colombia until 1903, the search was on for a buyer. Eventually, France found a friend in the United States of America. At the time, a canal in the Latin American isthmus was not a new idea to America, either. In 1887, the government sent ... ...he Hay-Bunau-Varilla treaty - which was ratified by the new Panamanian Government in 1903, and by the American Senate in early 1904. Before any work could begin, the most deadly of the problems on the isthmus had to be overcome - disease. The government wasn't going to allow mortality rates like had been seen during the French reign - somewhere between ten and twenty thousand were estimated to have died at the canal zone between 1882 and 1888. For this purpose, American doctor William Gorgas was called to examine the area. The most troublesome diseases were the mosquito-carried malaria and yellow fever - the same diseases that had kept Napoleon Bonaparte from putting down the uprising in Hati in 1801 - but almost all diseases known to man were endemic. Tuberculosis, cholera, diphtheria, smallpox, bubonic plague - all were cases on file at Panama hospitals in 1904.